Further investigation on the leaves of Isodon sculponeatus afforded two new ent-kaurane diterpenoids,sculponeatins J and K .Their sturctures were elucidated on the basis of their spectral properties,as well as X-ray crystallographic analysis ,The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested ,and sculponeation J showed significant inhibitory effects with IC50 values less than 1.0 μg/mL。

完成机构：[1]StakeKeyLaboratoryofPhytochemistryandPlantResourcesinestChina,KunmingInstituteofBotany,AcademiaSinica,Kurnming,Yunnan6500204,China [2]InstituteofMateriaMedica,ChineseAcademyofMed

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